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. Author manuscript; available in PMC: 2023 Oct 1.
Published in final edited form as: Neuropharmacology. 2023 Jun 15;237:109635. doi: 10.1016/j.neuropharm.2023.109635

Table 1.

Oxycodone pharmacokinetics analysis. The extrapolated concentration at timepoint 0 (C0), area under the curve (AUC), elimination constant (Ke), and half-life (t1/2) are shown for each of the four strains. Data are presented as mean ± S.E.M.

F344/N BN/NHsd ACI WKY/N
C0 (ng/mL) 87.2 ± 5.6 72.8 ± 10.5 97.8 ± 16.7 130 ± 25.3
AUC 6433 ± 636 4094 ± 714 6462 ± 915.2 9149 ± 1695
Ke 0.0092 ± 0.0010 0.0127 ± 0.0014 0.0113 ± 0.0011 0.0097 ± 0.0012
t1/2 (min) 83.8 ± 9.3 62.1 ± 11.8 74.7 ± 10.0 66.1 ± 7.0