Table 3. In vivo activity of P96 at a single oral dose of 200 mg/kg for 5 consecutive days against different developmental stages of S. japonicum in mice.
| Worm number (mean±SD)/worm reduction (%) | Chi-square test | P value | ||
|---|---|---|---|---|
| P96 (200 mg/kg) | PZQ (200 mg/kg) | |||
| Control a | 51.0 ± 2.1/0.0 | 51.0 ± 2.1/0.0 | / | / |
| 1-day-pi | 23.5 ± 3.5/53.9 | 37.0 ± 1.9/27.5 | χ2 = 7.428 | 0.006 |
| 3-day-pi | 28.8 ± 4.6/43.5 | 46.3 ± 4.6/9.8 | χ2 = 14.557 | <0.0001 |
| 7-day-pi | 28.5 ± 3.5/44.2 | 46.4 ± 3.4/9.0 | χ2 = 15.417 | <0.0001 |
| 14-day-pi | 21.3 ± 3.2/58.2 | 41.3 ± 2.7/19.9 | χ2 = 16.452 | <0.0001 |
| 21-day-pi | 27.6 ± 5.0/45.9 | 29.2 ± 3.3/42.7 | χ2 = 0.04 | 0.842 |
| 28-day-pi | 23.6 ± 2.3/53.6 | 16.7 ± 2.9/67.1 | χ2 = 1.998 | 0.157 |
| 35-day-pi | 6.7±0.58/86.9 | 1.7±0.6/96.7 | χ2 = 1.950 | 0.163 |
a: Mice were given an equal volume of corn oil, pi: post-infection.