Table 2.
Allopurinol altered gene expression is PSE cells, 2 days post treatment.
| Trt | Ki67 | p21 | IL17A | IL23A | TNFα | TGFβ |
|---|---|---|---|---|---|---|
| Control | 1.03 ± 0.19 | 1.00 ± 0.06 | 1.44 ± 0.79 | 1.00 ± 0.02 | 1.00 ± 0.01 | 1.00 ± 0.08 |
| 0.5 mM allopurinol | 0.27 ± 0.01 | 1.27 ± 0.10 | 0.21 ± 0.07 | 0.95 ± 0.20 | 0.75 ± 0.13 | 0.90 ± 0.09 |
| 3 mM allopurinol | 0.42 ± 0.09 | 1.40 ± 0.17 | 0.09 ± 0.04 | 0.66 ± 0.17 | 0.82 ± 0.19 | 0.6 ± 0.12 |
| 3 mM glutathione | 0.27 ± 0.01 | 1.35 ± 0.06 | 0.04 ± 0.02 | 0.79 ± 0.14 | 0.29 ± 0.07 | 0.77 ± 0.10 |
| 3 mM A+3 mM GSH | 0.16 ± 0.02 | 3.06 ± 0.03 | 0.03 ± 0.01 | 0.29 ± 0.03 | 0.23 ± 0.01 | 0.45 ± 0.04 |
| 100 nM VitD | 0.34 ± 0.01 | 5.10 ± 0.70 | 0.06 ± 0.03 | 0.45 ± 0.07 | 0.48 ± 0.17 | 0.35 ± 0.09 |