Table 1.
Clinical distribution characteristics of CHB patients with different immune states.
| Variables | Immune active | P value | ||||
|---|---|---|---|---|---|---|
| Immune tolerant (N = 259) | HBeAg positive (N = 365) | Inactive (N = 128) | HBeAg negative (N = 33) | Indeterminate phase (N = 441) | ||
| Age (year) | 32.0 (27.0–40.0) | 30.0 (26.0–37.0) | 42.0 (34.0–49.0) | 41.0 (37.0–47.0) | 41.0 (34.0–48.0) | <0.001 |
| Sex (male%) | 135 (52.1%) | 260 (71.2%) | 76 (59.4%) | 28 (84.8%) | 284 (56.2%) | <0.001 |
| WBC (×109/L) | 5.7 (4.7–6.9) | 5.4 (4.6–6.4) | 5.7 (4.6–6.4) | 5.8 (4.5–6.9) | 5.4 (4.5–6.6) | 0.241 |
| PLT (×109/L) | 198.0 (170.0–228.0) | 189.0 (154.5–223.0) | 189.0 (147.3–223.0) | 182.0 (133.0–222.5) | 174.0 (144.0–210.0) | <0.001 |
| PT (s) | 11.6 (11.1–12.1) | 11.6 (11.1–12.2) | 11.4 (11.0–12.0) | 11.4 (10.8–11.8) | 11.6 (11.1–12.2) | 0.025 |
| INR | 1.0 (1.0–1.1) | 1.0 (1.0–1.1) | 1.0 (1.0–1.1) | 1.0 (0.9–1.0) | 1.0 (1.0–1.1) | 0.002 |
| ALB (g/L) | 45.0 (42.3–47.5) | 45.0 (42.2–47.5) | 44.8 (43.2–46.7) | 45.3 (43.1–48.1) | 44.8 (42.2–47.3) | 0.766 |
| GLB (g/L) | 28.4 (25.3–30.6) | 28.5 (25.7–31.3) | 28.0 (28.8–31.0) | 28.2 (26.5–30.7) | 28.1 (25.5–31.6) | 0.875 |
| ALT (U/L) | 26.0 (19.0–32.0) | 71.0 (53.0–111.0) | 21.5 (15.3–30.5) | 55.0 (47.0–86.5) | 33.0 (22.0–54.0) | <0.001 |
| AST (U/L) | 24.0 (20.0–28.0) | 44.0 (35.0–65.5) | 23.0 (19.0–28.0) | 36.0 (31.0–59.5) | 29.0 (23.0–39.0) | <0.001 |
| GGT (U/L) | 16.0 (12.0–22.0) | 30.0 (20.0–49.0) | 17.5 (13.0–30.0) | 36.0 (23.5–56.0) | 23.0 (15.0–35.5) | <0.001 |
| ALP (U/L) | 68.0 (57.0–83.0) | 78.0 (64.0–93.0) | 71.5 (60.0–85.3) | 84.0 (74.0–95.0) | 78.0 (62.0–96.0) | <0.001 |
| TBIL (μmol/L) | 13.0 (9.2–16.6) | 14.0 (11.0–18.2) | 15.3 (11.8–18.1) | 15.7 (13.0–18.0) | 14.0 (10.8–18.2) | 0.002 |
| Log10 (HBV-DNA IU/ml) | 7.9 (7.3–8.4) | 7.5 (6.7–8.2) | 2.8 (2.4–3.1) | 2.6 (2.3–3.1) | 4.3 (3.7–5.3) | <0.001 |
| Log10 (HBsAg IU/ml) | 2.4 (2.4–4.7) | 3.4 (2.4–4.5) | 2.4 (2.3–2.4) | 2.4 (1.9–2.4) | 2.4 (2.4–3.3) | <0.001 |
| Anti-HBC (S/CO) | 8.9 ± 2.7 | 10.7 ± 2.4 | 10.3 ± 1.7 | 10.5 ± 1.5 | 11.2 ± 2.6 | <0.001 |
| Liver inflammation (%) | ||||||
| 0 | 4 (1.5) | 1 (0.3) | 2 (1.6) | 2 (6.1) | 2 (0.5) | <0.001 |
| 1 | 166 (64.1) | 162 (44.4) | 90 (70.3) | 18 (54.5) | 200 (45.4) | |
| 2 | 81 (31.3) | 152 (41.6) | 33 (25.8) | 11 (33.3) | 188 (42.6) | |
| 3 | 8 (3.1) | 47 (12.9) | 3 (2.3) | 2 (6.1) | 45 (10.2) | |
| 4 | 0 (0) | 3 (0.8) | 0 (0) | 0 (0) | 6 (1.4) | |
| Fibrosis (%) | ||||||
| 0 | 69 (26.6) | 49 (13.4) | 13 (10.4) | 2 (6.1) | 67 (15.2) | <0.001 |
| 1 | 121 (46.7) | 174 (47.7) | 55 (44.0) | 11 (33.3) | 161 (36.5) | |
| 2 | 56 (21.6) | 90 (24.7) | 44 (35.2) | 19 (57.6) | 122 (27.7) | |
| 3 | 7 (2.7) | 29 (7.9) | 9 (7.2) | 1 (3.0) | 48 (10.9) | |
| 4 | 6 (2.3) | 23 (6.3) | 7 (5.6) | 0 (0) | 43 (9.7) | |