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. 2023 Jul 6;3(7):829–845. doi: 10.1038/s43587-023-00442-w

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 4 — Aged hamsters and young hamsters were treated (or not) with ABT-263 and then infected with SARS-CoV-2. A, Body weight loss of vehicle-treated and ABT-263-treated aged hamsters and young hamsters following a SARS-CoV-2 infection (n = 6). B, Effect of ABT-263 treatment on the frequency of p16-positive cells (7 dpi) as assessed by immunohistochemistry. Arrows indicate p16-positive cells. Bars: 20 μm. C, The p16 transcript levels are indicated (n = 3-6). The data are expressed as the fold increase relative to average gene expression in infected (7 dpi) vehicle-treated young hamsters (n = 3-6). For all graphs, errors indicate mean ± s.d. One of two representative experiments are shown (A-C). Significance of body weight loss between animal groups was calculated using wilcoxon matched-pairs signed rank test (A). Significant differences were determined using One-way ANOVA Kruskal-Wallis test (nonparametric), followed by the Dunn’s posttest test (C).