Table 1.

GSEA analysis (lungs from uninfected young hamsters versus uninfected, aged hamsters)

GSEA name	MSigDBa	NESb	FDR q value	Directionc
GOBP_CILIUM_ORGANIZATION AND MOVEMENT	C5BP	2.96	<0.00001	Up
REACTOME_GPCR_LIGAND_BINDING	C2CP	−2.28	<0.00001	Down
REACTOME_ECM_PROTEOGLYCANS	C2CP	−2.1	0.0006	Down
GOBP_REGULATION_OF_BLOOD_PRESSURE	C5BP	−1.93	0.03	Down
GOBP_NEGATIVE_REGULATION_OF_LEUKOCYTE_APOPTOTIS	C5BP	−1.9	0.03	Down
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION	Hallmarks	−1.6	0.025	Down
HALLMARK_APICAL_JUNCTION	Hallmarks	−1.59	0.018	Down

^aName of the GSEA Molecular Signatures Database (MSigDB) used.

^bNormalized enrichment score (NES) calculated by GSEA software.

^cType of list used for GSEA analysis: upregulated genes (up) or downregulated genes (down) in aged lungs versus young lungs.