Extended Data Fig. 5. Equivalents of increased risk for incident coronary artery disease event identified by high GPS_Mult in the UK Biobank Study.

A: Cumulative incidence of coronary artery disease (CAD) events (%) over length of follow-up stratified by presence of prior peripheral artery disease (PAD) or no prior PAD with GPS_Mult in the middle quintile or top 8% of the population, estimated using Cox proportional-hazards regression model adjusted for age, sex, genotyping array, and the first ten principal components of ancestry in the European ancestry UK Biobank validation dataset. B: Cumulative incidence of CAD events (%) over length of follow-up stratified by presence of prior diabetes mellitus (DM) or no prior DM with GPS_Mult in the middle quintile or top 21% of the population, estimated using Cox proportional-hazards regression model adjusted for age, sex, genotyping array, and the first ten principal components of ancestry in the European ancestry UK Biobank validation dataset. C: Cumulative incidence of CAD events (%) over length of follow-up stratified by presence of prior severe hypercholesterolemia (estimated untreated low-density lipoprotein cholesterol, LDL-C 190 mg/dL or higher), or no prior hypercholesterolemia with GPS_Mult in the middle quintile or top 28% of the population, estimated using Cox proportional-hazards regression model adjusted for age, sex, genotyping array, and the first ten principal components of ancestry in the European ancestry UK Biobank validation dataset.