Extended Data Fig. 7. Association of GPS_Mult and risk factors with incident and recurrent coronary artery disease events.

Hazards ratio per standard deviation (HR/SD) with 95% confidence intervals of variable of interest for incident disease assessed in individuals without prior coronary artery disease (CAD) followed for development of first CAD event with Cox proportional hazards regression model adjusted for age, sex, genotyping array, and the first ten principal components of ancestry in the European ancestry validation dataset of the UK Biobank Study (N = 308,264 independent participants). HR/SD of variable of interest for recurrent disease assessed in individuals with prior CAD followed for development of recurrent CAD event with Cox proportional hazards regression model adjusted for age, sex, genotyping array, and the first ten principal components of ancestry. P values are derived from a Wald test implemented in the coxph function in R and are two-sided. *LDL-C, HDL-C, and triglyceride values were adjusted for cholesterol-lowering medication status, as previously described⁵⁷. BP: Blood pressure. BMI: Body-mass index. HgbA1c: Glycated hemoglobin. LDL-C: Low-density lipoprotein cholesterol. HDL-C: High-density lipoprotein cholesterol.