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. 2023 Jul 6;29(7):1793–1803. doi: 10.1038/s41591-023-02429-x

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a, Adjusted HR/SD of the polygenic score with corresponding 95% CIs and P values for incident CAD by ancestry, stratified by the version of the polygenic score, calculated from Cox proportional-hazards regression models adjusted for age, sex, genotyping array and the first ten principal components of ancestry in the UK Biobank validation dataset, consisting of n = 7,157 independent individuals of African ancestry, n = 1,442 independent individuals of East Asian ancestry, n = 297,772 independent individuals of European ancestry, and n = 8,440 independent individuals of South Asian ancestry. GPS₂₀₁₈ corresponds to a previously published polygenic score for CAD⁹. P values are derived from a Wald test implemented in the coxph function in R and are two-sided. b, The score effect sizes relative to the effect size of GPS₂₀₁₈ in European ancestry individuals. ‘>3-fold larger CAD GWAS’ designates a polygenic score generated using summary statistics of largely European ancestry from the most recent CARDIOGRAMplusC4D excluding the UK Biobank (GPS_CADEUR). ‘Multi-ancestry CAD GWAS’ refers to the polygenic score generated by combining ancestry-specific polygenic scores generated using GWAS summary statistics from CARDIOGRAMplusC4D, Genes & Health, Biobank Japan, Million Veteran Program and FinnGEN biobanks in layer 1 (GPS_CADANC). GPS_Mult designates polygenic score for CAD designed with summary statistics from multiple ancestries and multiple CAD-related traits in layer 2. Asterisk designates the reference group for calculating relative gain.