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. 2023 Jul 6;29(7):1793–1803. doi: 10.1038/s41591-023-02429-x

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 3 — Proportion of UK Biobank validation population with 3, 4, and 5-fold increased risk for CAD versus the middle quintile of the population identified by GPS₂₀₁₈ (A) and GPS_Mult (B). The odds ratio assessed in a logistic regression model adjusted for age, sex, genotyping array, and the first ten principal components of ancestry. Proportion of UK Biobank testing population with 1/3, 1/4, and 1/5 risk for CAD versus the middle quintile of the population, population identified by GPS₂₀₁₈ (C) and GPS_Mult (D). Odds ratio assessed in a logistic regression model adjusted for age, sex, genotyping array, and the first ten principal components of ancestry. GPS: Genome-wide polygenic score; CAD: coronary artery disease.