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. 2023 May 29;29(7):1775–1781. doi: 10.1038/s41591-023-02380-x

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a, Longitudinal tau–PET annual rate of change according to astrocyte reactivity status (n = 71). b, Association between tau–PET annual rate of change and baseline Aβ–PET according to astrocyte reactivity status. c, Percentage of voxels with significant association (after RFT correction) between tau–PET annual rate of change and baseline Aβ–PET in each Braak region. Associations were tested using voxel-wise linear regression models corrected for RFT multiple comparison and adjusted by age and sex.