Extended Data Table 1.

Associations between plasma p-tau181 and Aβ burden according to astrocyte reactivity status

Abbreviations: Ast−: reactive astrocyte negative; Ast+: reactive astrocyte positive; p-tau: phosphorylated tau. We inverted the values for plasma Aβ ratio in the analysis to pool plasma Aβ and Aβ-PET levels together. Covariates: age, sex, and cohort (when all studies were evaluated together). P-values were computed using linear regression models adjusted by age, sex, and cohort (when appropriate) for individuals classified as Ast− and Ast+. In addition, the Aβ burden × astrocyte reactivity status interaction was also computed.