Extended Data Table 3.

Sensitivity analysis adjusting for APOEε4 status

Abbreviations: Ast−: reactive astrocyte negative; Ast+: reactive astrocyte positive; p-tau: phosphorylated tau. We inverted the values for plasma Aβ ratio in the analysis to pool plasma Aβ and Aβ-PET levels together. P-values were computed using linear regression models adjusted by age, sex and cohort (when appropriate) for individuals classifies as Ast− and Ast+. In addition, the Aβ burden × astrocyte reactivity status interaction was also computed.