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. 2023 Jun 5;3(7):796–812. doi: 10.1038/s43587-023-00436-8

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 4 — a. Mitochondrial membrane potential. N = 90 cells, 3 independent experiments. Error bars reflect SEM; p-value determined by one-way ANOVA. b. Normalized luminescent measurements of ATP. N = 6 biological repeats. Error bars reflect SEM; p-value determined by one-way ANOVA. c. Mitochondrial counts. N = 30–45 cells, 3 independent experiments. Error bars reflect SEM; p-value significance according to Welch’s t-test, two-tailed. d. Mitochondrial area. N = 30–45 cells, 3 independent experiments. Error bars reflect SEM; not statistically significant according to Welch’s t-test, two-tailed. e. Mitochondrial roundness. N = 30–45 cells, 3 independent experiments. Error bars reflect SEM; not statistically significant according to Welch’s t-test, two-tailed. f. Mitochondrial branches. N = 30–45 cells, 3 independent experiments. Error bars reflect SEM; not statistically significant according to Welch’s t-test, two-tailed. g. Representative images of BMDMs-Y and BMDMs-O immunostained for TOM20. Scale bar at 10 µm. h. Cytosolic Ca²⁺ Oscillations in BMDMs-Y (n = 88 cells) and BMDMs-O (n = 87 cells). i. Cytosolic Ca²⁺ Oscillations with ATP. j. Maximum cytosolic Ca²⁺. N = 112 cells, 2 independent experiments. Whiskers represent the min to max values for each data set. Box represents 75^th and 25^th percentile. Line is at the median; p-value according to Welch’s t-test, two-tailed. k. Number of oscillations in individual cells. N = 112 cells, 2 independent experiments. Whiskers represent the min to max values for each data set. Box represents 75^th and 25^th percentile. Line is at the median; p<value according to Welch’s t-test, two-tailed. l. Oscillation length in individual cells. N = 112 cells, 2 independent experiments. Whiskers represent the min to max values for each data set. Box represents 75^th and 25^th percentile. Line is at the median; p<0.0001 according to Welch’s t-test, two-tailed. m. Cytosolic Ca²⁺ Oscillations with OxPAPC. n. Maximum cytosolic Ca²⁺. N = 104 cells, 2 independent experiments Whiskers represent the min to max values for each data set. Box represents 75^th and 25^th percentile. Line is at the median; p-value according to Welch’s t-test, two-tailed. o. Number of oscillations in individual cells. N = 104 cells, 2 independent experiments. Whiskers represent the min to max values for each data set. Box represents 75^th and 25^th percentile. Line is at the median; p<value according to Welch’s t-test, two-tailed. p. Oscillation length in individual cells. N = 104 cells, 2 independent experiments. Whiskers represent the min to max values for each data set. Line is at the median; p<0.0001 according to Welch’s t-test, two-tailed.

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