Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Jun 5;3(7):796–812. doi: 10.1038/s43587-023-00436-8

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Extended Data Fig. 1 — a. Variance in gene expression in whole blood of different age groups based on Principal Component analysis on GTEx samples. b. GO pathway enrichment analysis based on DSeq2 from GTEx samples. Differential gene expression is plotted for ages 60–69 vs 20–29. Significance determined by Dotplot function (clusterProfiler R package¹). c. Pipeline used for the analysis of genes encoding for mitochondria-localized proteins (mito-genes). d. Principal component analysis on mito-genes from GTEx samples. Variance in gene expression is shown for individual age groups. e. Variance in gene expression shown for age 20–29 vs 60–69, 30–39 vs 60–69, 40–49 vs 60–69, and 50–59 vs 60–69. f. Volcano plot of mito-genes expression levels in old (60–69y) vs young (20–29y) samples. Data normalization, dispersion estimates, and model fitting (negative binomial) were carried out with the DESeq function (DESeq2 R package). Wald statistics were used for the significance tests. g. MICU2, EMRE, and MCUB gene counts for each sample in GTEx database sorted by age. Error bars reflect SEM; p-values were calculated using one-way ANOVA.

Source data