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. 2023 Feb 21;48(9):1328–1337. doi: 10.1038/s41386-023-01551-1

Fig. 5. Chronic corticosterone treatment decreases phosphorylation of the dopamine transporter (DAT) at threonine-53 in the dorsomedial striatum (DMS) of male mice.

Fig. 5

A Experimental timeline for pellet implantation, tissue punches, and western blot experiments. B Representative western blots for phosphorylated DAT at threonine-53 (‘pDAT’), DAT, and beta-actin (‘Actin’) from DMS tissue samples of male mice (top) and female mice (bottom). C Membrane-bound DAT expression, normalized to Actin and plotted as a percent of Placebo expression, from DMS tissue samples of male mice. D Membrane-bound DAT expression, normalized to Actin and plotted as a percent of Placebo expression, from DMS tissue samples of female mice. E pDAT expression, normalized to DAT and plotted as a percent of Placebo expression, from DMS tissue samples of male mice. Unpaired two-tailed t-test *p < 0.05. F pDAT expression, normalized to DAT and plotted as a percent of Placebo expression, from DMS tissue samples of female mice. Each point represents a single individual. Data presented as mean ± SEM.