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. 2023 May 23;48(9):1309–1317. doi: 10.1038/s41386-023-01608-1

Fig. 2. D2R upregulation in NAc CINs does not alter probabilistic discounting.

Fig. 2

A Schematic illustration of probabilistic discounting task. On free choice trials, two lever options are presented, each leading to a small or a large reward. The probability of receiving the large reward is progressively decreased across sessions (100–20%), while the small reward is always given. B With increased training, both EGFP and D2R-overexpressing mice increased preference for the large reward when both options were equally probable to yield reward (100%) probability; session block effect: F (6, 84) = 17.85, p < 0.0001; Tukey’s test showed significant differences between session blocks 1 and 7 for both groups (adjusted p values < 0.0001). No significant main effects of virus (F (1, 14) = 0.08267, p = 0.7779) or virus x session block interactions (F (6, 84) = 0.9243, p = 0.4818) were observed. C. A significant main effect of probability was detected (F(6, 84) = 38.39, p < 0.0001), with both groups showing significant simple main effects within-group (100% vs. 33% or 20%, adjusted p values < 0.0001), but this effect was not significantly different following D2R upregulation (virus: F (1, 14) = 0.8632, p = 0.3686; virus x probability: F (6, 84) = 0.7642, p = 0.6001, n = 8 mice/group). EGFP: 3 males, 5 females; D2: 4 males, 4 females.