Fig. 1. 5-MeO-DMT elicits a briefer duration of head-twitch response than psilocybin.

A Schematic of a C57BL/6 J mouse with a magnetic ear tag. B Head-twitch response counted manually from video recordings versus automatically via the magnetic ear tag system. R² = 0.996. C Head-twitch response as a function of time after systemic administration of varying doses of 5-MeO-DMT, saline, or 1 mg/kg psilocybin. D Total number of head-twitch response for 2 h period after systemic administration. E Duration of head-twitch response, quantified by calculating the full-width half-maximum from the time course in (C). For (B), n = 14 mice. For (C–E), n = 34 mice (3 males and 3 females for each condition, except 3 males and 1 female for saline condition).