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. 2023 Apr 4;48(9):1257–1266. doi: 10.1038/s41386-023-01572-w

Fig. 3. 5-MeO-DMT increases the density of dendritic spines, but does not affect spine size, in the mouse medial frontal cortex.

Fig. 3

A Imaging setup. B Timeline for longitudinal imaging. C Example field of view in a mouse treated with 20 mg/kg 5-MeO-DMT. Scale bar, 5 μm. D Effects of vehicle or 20 mg/kg 5-MeO-DMT on spine density, plotted as fold-change relative to baseline Day −3. Mean ± SEM. E Effects of vehicle or 20 mg/kg 5-MeO-DMT on spine head width, plotted as fold-change relative to baseline Day −3. Mean ± SEM. n = 6 mice for 5-MeO-DMT and 4 mice for saline.