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. 2023 Jul 18;13:11584. doi: 10.1038/s41598-023-38415-z

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Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Time-dynamic associations between relapses and worsening outcomes in ROMS. The posterior means (black lines) and 95% credible intervals (dash lines) are time-varying estimates of association parameters obtained from the VCJM. The grey solid lines denote the time-fixed estimates of the association parameters obtained from CCJM.