Table 3.
Results of the CCJM: Posterior means (Est) and 95% credible intervals (C.I.) for the parameters in the current value (CV) and current slope (CS) model.
| Model components | Unadjusted model | DMT-adjusted model |
|---|---|---|
| Effects | Estimates (95% C.I) | Estimates (95% C.I.) |
| Analyses of time-to-relapses (N = 2453, D2 = 856 relapsing events) | ||
| Clinical and environmental effects | ||
| Sex [male] | − 0.471 (− 0.497; − 0.445) | − 0.186 (− 0.205; − 0.168) |
| Log (age) at onset | 0.009 (0.008; 0.010) | − 0.015 (− 0.016; − 0.013) |
| Body mass index | − 0.114 (− 0.159; − 0.069) | 0.374 (0.322; 0.426) |
| Relapse counts | 0.312 (0.303; 0.320) | 0.390 (0.379; 0.402) |
| T2 lesion load | 0.182 (0.154; 0.210) | 0.020 (0.009; 0.031) |
| Vitamin D supplementation [Yes] | − 0.180 (− 0.241, − 0.118) | − 0.170 (− 0.212; − 0.129) |
| Association parameters | ||
| WS-GPI [value] | 0.919 (0.892; 0.945) | 1.086 (1.068; 1.104) |
| WS-GPI [slope] | 0.895 (0.652; 1.138) | 1.207 (1.063; 1.351) |
| WS-GPI [value] DDMT (Cat. 1) | − 0.387 (− 0.542; − 0.233) | |
| WS-GPI [slope] DDMT (Cat. 1) | − 0.648 (− 0.879; − 0.417) | |
| WS-GPI [value] DDMT (Cat. 3) | − 0.984 (− 1.142; − 0.827) | |
| WS-GPI [slope] DDMT (Cat. 3) | 1.207 (1.063; 1.351) | |
| Analyses of time-to-worsening of disability (N = 2453, D1 = 481 worsening events) | ||
| Clinical and environmental effects | ||
| Sex [male] | − 1.908 (− 1.948; − 1.868) | − 1.431 (− 1.472; − 1.390) |
| Log (age) at onset | − 0.014 (− 0.015; − 0.013) | − 0.015 (− 0.015; − 0.014) |
| Body mass index | 0.025 (0.022; 0.027) | 0.018 (0.017; 0.020) |
| Relapse counts | 0.080 (0.067; 0.094) | − 0.005 (− 0.014; 0.004) |
| T2 lesion load | 0.949 (0.920; 0.977) | 0.613 (0.587; 0.639) |
| Vitamin D supplementation [Yes] | − 0.051 (− 0.077; − 0.025) | − 0.081 (− 0.107; − 0.056) |
| Association parameters | ||
| RS-GPI [value] | 1.513 (1.436; 1.589) | 1.238 (1.192; 1.284) |
| RS-GP [slope] | − 2.517 (− 3.259; − 1.774) | − 1.580 (− 1.880; − 1.280) |
| RS-GPI [value] DDMT (Cat. 1) | − 0.302 (− 0.365; − 0.239) | |
| RS-GP [slope] DDMT (Cat. 1) | 0.443 (− 0.151; 1.037) | |
| RS-GPI [value] DDMT (Cat. 3) | − 0.110 (− 0.165; − 0.055) | |
| RS-GP [slope] DDMT (Cat. 3) | 0.365 (− 0.192; 0.922) | |
DDMT (Cat. 1): Duration of DMT category 1.
DDMTs (Cat. 3): Duration of DMT category 3.
WS-GPI [value]: Current value of the WS-GPI.
WS-GPI [slope]: Current slope of WS-GPI.
RS-GPI [value]: Current value of the RS-GPI.
RS-GPI [slope]: Current slope of RS-GPI.