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. 2023 Apr 17;48(9):1409–1417. doi: 10.1038/s41386-023-01579-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Spearman correlation between DunedinPoAm (years of physiological change per chronological year) (A, C) on the y-axis and childhood maltreatment measured by CTQ score or cumulative lifetime stress measured by MEL score on the x-axis (Spearman correlation coefficient, r_s). B displays a box plot and a p-value from a t-test of dichotomized childhood maltreatment status – abused (N = 149) vs. not abused (N = 191). The status abused was given if participant had moderate or severe abuse in any of the subscales of the questionnaire. Data was missing for 80 participants. D displays a box plot and a p-value from a t-test of dichotomized cumulative lifetime stress status – low (N = 128) vs. high (N = 115) lifetime stress categorized by the median score of the participants (median=18). This questionnaire was only available in the BeCOME cohort and was missing for 56 participants. ****P ≤ 0.0001; ***p ≤ .001; **p ≤ .01, *p ≤ .05. ns not significant.