Table 1.
Demographics of cohorts.
| BeCOME (N = 301) | OPTIMA (N = 119) | Overall (N = 420) | |
|---|---|---|---|
| Age (years) | |||
| Mean (SD) | 35.3 (12.1) | 42.9 (13.5) | 37.4 (12.9) |
| Median [Min, Max] | 31.8 [18.7, 66.2] | 44.7 [19.2, 73.6] | 34.0 [18.7, 73.6] |
| Sex | |||
| Female | 193 (64.1%) | 65 (54.6%) | 258 (61.4%) |
| Male | 108 (35.9%) | 54 (45.4%) | 162 (38.6%) |
| Ethnicity | |||
| African | 1 (0.3%) | 0 (0%) | 1 (0.2%) |
| Asian | 6 (2.0%) | 0 (0%) | 6 (1.4%) |
| Caucasian | 267 (88.7%) | 94 (79%) | 361 (86.0%) |
| Hispanic/Latin-american | 3 (1.0%) | 0 (0%) | 3 (0.7%) |
| Oriental | 7 (2.3%) | 0 (0%) | 7 (1.7%) |
| Other | 10 (3.3%) | 0 (0%) | 10 (2.4%) |
| Unknown | 2 (0.7%) | 0 (0%) | 2 (0.5%) |
| Missing | 5 (1.7%) | 25 (21.0%) | 30 (7.1%) |
| BMI (kg/m2) | |||
| Mean (SD) | 23.8 (4.57) | 26.6 (5.97) | 24.6 (5.16) |
| Median [Min, Max] | 22.7 [15.4, 47.6] | 25.6 [17.3, 52.9] | 23.2 [15.4, 52.9] |
| Missing | 8 (2.7%) | 0 (0%) | 8 (1.9%) |
| Smoking status | |||
| Current smoker | 1 (0.3%) | 4 (3.4%) | 5 (1.2%) |
| Former smoker | 165 (54.8%) | 90 (75.6%) | 255 (60.7%) |
| Never smoker | 135 (44.9%) | 25 (21.0%) | 160 (38.1%) |
| Childhood maltreatment | |||
| Mean (SD) | 39.7 (14.4) | 43.8 (15.3) | 40.9 (14.8) |
| Median [Min, Max] | 35.0 [25.0, 88.0] | 41.0 [25.0, 96.0] | 37.0 [25.0, 96.0] |
| Missing | 58 (19.3%) | 22 (18.5%) | 80 (19.0%) |
| Lifetime stress | |||
| Mean (SD) | 19.9 (13.0) | - | 19.9 (13.0) |
| Median [Min, Max] | 18.0 [0, 59.0] | - | 18.0 [0, 59.0] |
| Missing | 58 (19.3%) | 119 (100%) | 177 (42.1%) |
| Burden of psychiatric disease | |||
| Mean (SD) | 5.87 (5.53) | 9.37 (5.02) | 6.89 (5.61) |
| Median [Min, Max] | 4.0 [0, 33.0] | 9.0 [2.0, 24.0] | 6.0 [0, 33.0] |
| Missing | 21 (7.0%) | 4 (3.4%) | 25 (6.0%) |
| School education | |||
| 12-13 years | 200 (66.4%) | 45 (37.8%) | 245 (58.3%) |
| 12 years | 20 (6.6%) | 17 (14.3%) | 37 (8.8%) |
| 10 years | 32 (10.6%) | 17 (14.3%) | 49 (11.7%) |
| 9 years | 14 (4.7%) | 19 (16.0%) | 33 (7.9%) |
| No school graduation | 0 (0%) | 3 (2.5%) | 3 (0.7%) |
| Still in school | 1 (0.3%) | 0 (0%) | 1 (0.2%) |
| Other | 5 (1.7%) | 5 (4.2%) | 10 (2.4%) |
| Missing | 29 (9.6%) | 13 (10.9%) | 42 (10.0%) |
Childhood maltreatment was evaluated with CTQ. Lifetime stress was evaluated with MEL and was available only in the BeCOME cohort. Burden of psychiatric disease was evaluated with the computer-based modified version of the Munich-Composite International Diagnostic Interview (DIA-X/M-CIDI).