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. 2023 Jul 18;14:4294. doi: 10.1038/s41467-023-39762-1

Fig. 2. Fibroblast heterogeneity in breast cancer.

Fig. 2

a Heatmap of the top six differentially expressed genes for each cell type in scRNA-seq data of all stromal cells (n = 16,704). Cellular phenotypes are indicated above the heatmap. Key marker genes are highlighted in red. b UMAP of all stromal cells coloured by CAF type, together with the corresponding feature plots showing the expression level of selected marker genes for each cell. c Gene set enrichment analysis comparing the enrichment of hallmark pathways between CAF types. Boxes indicate the functional hallmark pathways that we used to define/annotate CAF types (see also Supplementary Data 7). d Proportion of all CAF types and pericytes per patient. e Heatmap showing the average gene expression level of all defined marker genes per identified cell type (after batch correction).