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. 2023 Jul 18;13:11612. doi: 10.1038/s41598-023-38108-7

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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A KA-Search for sequence matches to the heavy variable domain of the SARS-CoV-2 RBD binding antibody COVOX-253. Returned antibodies with over 90% identity across four different regions were visualised based on, (a) the disease state of the patient and, (b) which V- and J-genes the antibody sequence is derived from. The y-axis is scaled logarithmically to better visualise the data. c, The variable domain of COVOX-253’s heavy (purple) and light (grey) chain with the bound spike glycoprotein (beige), derived from PDB 7BEN. The paratope of the heavy chain, which was used to search with KA-Search, is shown in red.