ESICM guidelines on acute respiratory distress syndrome: definition, phenotyping and respiratory support strategies

. 2023 Jun 16;49(7):727–759. doi: 10.1007/s00134-023-07050-7

Recommendation 6.2
We are unable to make a recommendation for or against PEEP titration guided principally by respiratory mechanics, compared to PEEP titration based principally on PEEP/FiO₂ strategy, to reduce mortality in patients with ARDS. No recommendation; high level of evidence of no effect.
This statement applies also to ARDS from COVID-19. No recommendation; moderate level of evidence for indirectness.

Recommendation 6.2

We are unable to make a recommendation for or against PEEP titration guided principally by respiratory mechanics, compared to PEEP titration based principally on PEEP/FiO₂ strategy, to reduce mortality in patients with ARDS.

No recommendation; high level of evidence of no effect.

This statement applies also to ARDS from COVID-19.

No recommendation; moderate level of evidence for indirectness.