Table 3.
Multivariable associations between pre-transplant characteristics and post-transplant cinacalcet use using imputed data, N=30,127
| Variables | IRR (99% CI) | P-value |
|---|---|---|
| Year of Transplant (referent is 2007) | 0.2 | |
| 2008 | 0.8 (0.8–1) | |
| 2009 | 0.7 (0.8–1.1) | |
| 2010 | 0.8 (0.9–1.2) | |
| 2011 | 0.8 (1–1.4) | |
| 2012 | 1.1 (1.1–1.5) | |
| 2013 | 1 (1.2–1.6) | |
| Age (vs 18–44) | 0.001 | |
| 45–64 | 1.5 (1.2–2) | |
| ≥65 BMI, kg/m2 (vs <18.5) |
1.5 (1–2.1) | 0.2 |
| 18.5–25 | 1.5 (0.6–3.9) | |
| 25–30 | 1.4 (0.5–3.5) | |
| ≥30 | 1.2 (0.5–3.2) | |
| Female | 1.3 (1.1–1.6) | 0.002 |
| Race (white is referent) | 0.02 | |
| Black | 0.8 (0.6–1) | |
| Other | 0.7 (0.5–1.1) | |
| Dialysis Vintage, years (vs <2) | <0.001 | |
| 2 to <5 | 2.2 (1.5–3.3) | |
| ≥5 | 3.7 (2.5–5.6) | |
| Hemodialysis (vs peritoneal dialysis) | 0.8 (0.6–1.1) | 0.1 |
| Cause of ESKD (glomerulonephritis is referent) | 0.002 | |
| Diabetes | 1.3 (0.9–1.9) | |
| Hypertension | 1.1 (0.8–1.7) | |
| Other | 1.7 (1.1–2.4) | |
| Cerebrovascular Disease | 1.2 (0.8–1.8) | 0.2 |
| Coronary Artery Disease | 0.7 (0.4–1.2) | 0.1 |
| Lung Disease | 0.8 (0.6–1.1) | 0.1 |
| Alcohol | 0.8 (0.6–1.1) | 0.07 |
| Hypertension | 1.1 (0.7–1.8) | 0.5 |
| Valvular Disease | 1.1 (0.7–1.7) | 0.7 |
| Diabetes Mellitus | 0.8 (0.6–1.1) | 0.09 |
| Peripheral Vascular Disorder | 1.1 (0.8–1.5) | 0.4 |
| Previous Solid Organ Transplant | 1.3 (0.7–2.5) | 0.3 |
| Donor blood type (O is referent) | 0.09 | |
| A | 0.9 (0.7–1.1) | |
| B | 1 (0.7–1.3) | |
| AB | 0.5 (0.2–1.1) | |
| Donor Age, years | 1 (1–1) | 1.0 |
| Cold Ischemia, hours | 1 (1–1) | 0.4 |
| Pre-Transplant Cinacalcet Use | 6 (4.7–7.8) | <0.001 |
Preselected variables = transplant year, age at transplant, sex, dialysis vintage, and dialysis modality. Other variables were selected using backward selection. Abbreviations: BMI, body mass index; ESKD, end stage kidney disease; IRR, incident rate ratio; CI, confidence interval