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. 2023 Jul 5;14:1224352. doi: 10.3389/fimmu.2023.1224352

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Copyright © 2023 Arrindell and Desnues

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Implication of vimentin in the immune response. (A) Intracellular vimentin implications of the initiation or facilitation of an immune response to a signal. Extracellular vimentin is also detected by Dectin-1, which initiates the production of intracellular ROS. The vimentin network plays an important role in anchoring or transporting essential proteins implicated in the immune response. (B) Extracellular vimentin is implicated in the recognition of apoptotic cells via its lectin-like domain. The response of an infection by a pathogen can increase extracellular vimentin, which can be detected by circulating immune cells.