Table 1.

Association of genetically predicted gut microbiota with non-alcoholic fatty liver disease.

Methods	IVs	OR	95% CI	p value	Egger intercept, p value	Heterogeneity (Q, p value)	MR-PRESSO (Global test p value)
Anaerotruncus
IVW	13	0.595	0.378-0.937	0.0249	-0.003, 0.952	11.377, 0.497	0.494
Weighted median	13	0.519	0.273-0.985	0.0449
MR-Egger	13	0.625	0.119-3.301	0.5914
MR-PRESSO	13	0.595	0.382-0.926	0.0400
Intestinimonas
IVW	17	0.726	0.550-0.958	0.0237	0.010, 0.761	18.312, 0.306	0.337
Weighted median	17	0.787	0.544-1.140	0.2049
MR-Egger	17	0.651	0.308-1.376	0.2785
MR-PRESSO	17	0.726	0.550-0.958	0.0380
Lachnoclostridium
IVW	13	0.523	0.297-0.920	0.0245	-0.087, 0.234	18.982, 0.089	0.107
Weighted median	13	0.429	0.225-0.816	0.0099
MR-Egger	13	1.893	0.237-15.130	0.5593
MR-PRESSO	13	0.523	0.297-0.920	0.0441
Lachnospiraceae NC2004 group
IVW	9	0.676	0.505-0.904	0.0083	-0.046, 0.542	7.121, 0.524	0.464
Weighted median	9	0.694	0.455-1.058	0.0891
MR-Egger	9	0.998	0.290-3.466	0.9967
MR-PRESSO	9	0.676	0.514-0.889	0.0233
Olsenella
IVW	11	0.770	0.623-0.953	0.0163	-0.060, 0.405	4.987, 0.892	0.897
Weighted median	11	0.743	0.562-0.982	0.0370
MR-Egger	11	1.257	0.410-3.854	0.6979
MR-PRESSO	11	0.770	0.663-0.895	0.0067
Peptococcus
IVW	12	0.817	0.669-0.998	0.0472	0.023, 0.690	14.159, 0.224	0.265
Weighted median	12	0.941	0.736-1.203	0.6284
MR-Egger	12	0.683	0.283-1.646	0.4156
MR-PRESSO	12	0.817	0.669-0.998	0.0472
Ruminococcus 1
IVW	10	1.833	1.142-2.940	0.0120	-0.023, 0.670	7.555, 0.580	0.897
Weighted median	10	1.800	0.920-3.523	0.0862
MR-Egger	10	2.435	0.635-9.332	0.2305
MR-PRESSO	10	1.833	1.188-2.826	0.0228

IV, instrumental variables; OR, Odd Ratio; IVW, inverse variance weighted; Bold represents p < 0.05.