Table 2.
Association of genetically predicted gut microbiota with alcoholic liver disease.
| Methods | IVs | OR | 95% CI | p value | Egger intercept, p value | Heterogeneity (Q, p value) | MR-PRESSO (Global test p value) |
|---|---|---|---|---|---|---|---|
| Ruminococcaceae UCG 002 | |||||||
| IVW | 20 | 1.263 | 1.014-1.572 | 0.0371 | -0.030, 0.196 | 13.997, 0.784 |
0.797 |
| Weighted median | 20 | 1.337 | 0.980-1.824 | 0.0670 | |||
| MR-Egger | 20 | 1.812 | 1.024-3.206 | 0.0561 | |||
| MR-PRESSO | 20 | 1.263 | 1.046-1.524 | 0.0252 | |||
| Lachnospira | |||||||
| IVW | 6 | 0.568 | 0.332-0.971 | 0.0388 | 0.149, 0.148 | 6.680, 0.246 |
0.278 |
| Weighted median | 6 | 0.672 | 0.355-1.273 | 0.2227 | |||
| MR-Egger | 6 | 0.049 | 0.003-0.745 | 0.0956 | |||
| MR-PRESSO | 6 | 0.568 | 0.332-0.971 | 0.0454 | |||
| Desulfovibrio | |||||||
| IVW | 10 | 0.744 | 0.574-0.964 | 0.0252 | 0.025, 0.532 |
4.043, 0.906 |
0.907 |
| Weighted median | 10 | 0.772 | 0.553-1.077 | 0.1272 | |||
| MR-Egger | 10 | 0.584 | 0.271-1.260 | 0.2076 | |||
| MR-PRESSO | 10 | 0.744 | 0.625-0.885 | 0.0087 | |||
| Ruminococcus torques group | |||||||
| IVW | 7 | 0.621 | 0.398-0.970 | 0.0364 | 0.006, 0.910 | 1.726, 0.943 |
0.945 |
| Weighted median | 7 | 0.571 | 0.319-1.022 | 0.0592 | |||
| MR-Egger | 7 | 0.574 | 0.146-2.259 | 0.4633 | |||
| MR-PRESSO | 7 | 0.621 | 0.489-0.789 | 0.0080 | |||
IV, instrumental variables; OR, Odd Ratio; IVW, inverse variance weighted; Bold represents p < 0.05.