Table 4.

Association of genetically predicted gut microbiota derived metabolites with non-alcoholic fatty liver disease.

Methods	IVs	OR	95% CI	p value	Egger intercept, p value	Heterogeneity (Q, p value)	MR-PRESSO (Global test p value)
Alanine
IVW	33	19.586	2.206-173.934	0.0076	-0.005 0.896	66.480, 0.001	0.067
Weighted median	33	3.814	0.289-50.406	0.3095
MR-Egger	33	33.147	0.010-110573	0.4041
MR-PRESSO	33	19.584	2.206-173.934	0.0118
Phenyllactate
IVW	17	0.212	0.065-0.689	0.0100	-0.006, 0.873	22.769, 0.120
Weighted median	17	0.384	0.093-1.588	0.1863			0.183
MR-Egger	17	0.289	0.005-15.218	0.5486
MR-PRESSO	17	0.212	0.065-0.689	0.0203
Stachydrine
IVW	6	2.228	1.109-4.474	0.0244	-0.052, 0.237	13.221, 0.104
Weighted median	6	2.211	0.898-5.444	0.0843			0.454
MR-Egger	6	3.148	0.228-43.387	0.4398
MR-PRESSO	6	2.228	1.109-4.474	0.0342

IV, instrumental variables; OR, Odd Ratio; IVW, inverse variance weighted; Bold represents p < 0.05.