Table 5.
Association of genetically predicted gut microbiota derived metabolites with alcoholic liver disease.
| Methods | IVs | OR | 95% CI | p value | Egger intercept, p value | Heterogeneity (Q, p value) | MR-PRESSO (Global test p value) |
|---|---|---|---|---|---|---|---|
| Phenylacetate | |||||||
| IVW | 9 | 0.496 | 0.258-0.953 | 0.0353 | 0.025, 0.274 | 4.928, 0.765 | 0.656 |
| Weighted median | 9 | 0.399 | 0.166-0.958 | 0.0399 | |||
| MR-Egger | 9 | 0.335 | 0.133-0.841 | 0.0526 | |||
| MR-PRESSO | 9 | 0.496 | 0.297-0.828 | 0.0278 | |||
| Threonate | |||||||
| IVW | 18 | 1.570 | 1.028-2.397 | 0.0370 | -0.013, 0.333 | 6.562, 0.989 | |
| Weighted median | 18 | 1.885 | 1.018-3.490 | 0.0436 | 0.972 | ||
| MR-Egger | 18 | 1.965 | 1.066-3.619 | 0.0457 | |||
| MR-PRESSO | 18 | 1.570 | 1.206-2.042 | 0.0037 | |||
| Ursodeoxycholate | |||||||
| IVW | 11 | 0.662 | 0.476-0.921 | 0.0144 | -0.004, 0.851 | 4.814, 0.903 | |
| Weighted median | 11 | 0.696 | 0.425-1.137 | 0.1480 | 0.931 | ||
| MR-Egger | 11 | 0.693 | 0.392-1.224 | 0.2381 | |||
| MR-PRESSO | 11 | 0.662 | 0.527-0.833 | 0.0055 | |||
IV, instrumental variables; OR, Odd Ratio; IVW, inverse variance weighted; Bold represents p < 0.05.