Table 2.
Clinicopathological risk factors for post-hepatectomy liver failure in patients with hepatocellular carcinoma.
| Variables | Univariable analysis | Multivariable analysis | ||
|---|---|---|---|---|
| OR (95% CI) | p-value | OR (95% CI) | p-value | |
| Gender | ||||
| Male vs. female | 1.62 (0.58–4.54) | 0.357 | ||
| Age (years) | ||||
| > 55 vs. ≤ 55 | 1.29 (0.65–2.58) | 0.463 | ||
| BMI (kg/m2) | ||||
| ≤ 18.5 vs. > 18.5 | 2.96 (0.35–25.21) | 0.285 | ||
| Etiology of hepatitis | ||||
| HBV vs. none/others | 1.14 (0.53–2.46) | 0.741 | ||
| Cirrhosis status | ||||
| Present vs. absent | 1.02 (0.54–1.95) | 0.949 | ||
| ALT (IU/L) | ||||
| > 42 vs. ≤ 42 | 1.59 (0.83–3.04) | 0.165 | ||
| AST (IU/L) | ||||
| > 42 vs. ≤ 42 | 2.30 (1.20–4.43) | 0.013 | 1.69 (0.82–3.48) | 0.153 |
| Platelet (×109/L) | ||||
| ≤ 125 vs. > 125 | 2.43 (1.26–4.73) | 0.008 | 2.50 (1.22–5.17) | 0.013 |
| Child–Pugh grade | ||||
| B vs. A | 1.45 (0.13–16.33) | 0.764 | ||
| ALBI score | ||||
| Grade 2/3 vs. Grade 1 | 3.65 (1.73–7.68) | 0.001 | 3.20 (1.46–7.00) | 0.004 |
| ICG-R15 test | ||||
| > 10% vs. ≤ 10% | 7.84 (2.57–23.92) | <0.001 | 4.87 (1.5–16.02) | 0.009 |
| Tumor size (cm) | ||||
| ≤ 5 vs. > 5 | 1.18 (0.62–2.25) | 0.619 | ||
| Resection extent | ||||
| Major vs. minor | 1.27 (0.63–2.55) | 0.507 | ||
| Laparoscopic operation | ||||
| Yes vs. no | 1.06 (0.42–2.47) | 0.903 | ||
| Intraoperative blood loss (ml) | ||||
| > 400 vs. ≤ 400 | 1.37 (0.63–2.96) | 0.421 | ||
| Liver resection time (min) | ||||
| > 60 vs. ≤ 60 | 1.44 (0.61–3.44) | 0.407 | ||
| MELD score | ||||
| > 9 vs. ≤ 9 | 1.30 (0.38–4.44) | 0.671 | ||
ALBI score, albumin–bilirubin score; ALT, alanine transaminase; AST, aspartate transaminase; BMI, body mass index; CI, confidence interval; HBV, hepatitis B virus; ICG-R15, indocyanine green retention rate at 15 min; MELD score, Model for End-Stage Liver Disease score; OR, odds ratio.