Bisphenol A-induced metabolic alterations in experimental animals.

Sr. #	Animal models	BPA doses	BPA induced effects	Ref.
1	Adult wistar rats	250 mg per kg per day for 28 days	Alter biochemical parameters, including blood urea nitrogen, creatinine and uric acids levels and induce the renal toxicity	52
2	F344 female rats	120 mg per kg per day	BPA exposure by lactational and transplacental induce insignificant adverse effects on spermatogenesis and male sex organs	57
3	Mice	100 μg per kg per day or 500 μg per kg per day	Log term BPA exposure induces anxiety-like symptom such as dizziness and cognitive deficits	58
4	Rat	50 μg kg−1	A massive rise in oxytocin immunoreactive cell number especially in the pra ventricular nucleus in female rats	59
5	Pregnant mice	10 mg per kg per day for 8 days	Disturb the placental functions and can induce the abortion	60
6	Male adult swiss mice	25 and 100 μg kg−1	Impaired male fertility and spermatogenesis	61
7	Pregnant mice	500 mg per kg per day	Induce reproductive toxicity in the male offspring	62
8	Male C57BL/6 mice	50 μg per kg per day	Induce intestinal or gut injury	63
9	Mice and rats	200 mg per kg per day	Dietary BPA intake is less toxic on sex accessory organs than subcutaneous or intraperitoneal BPA exposure	64
10	Mice	2 ng g−1 and 20 ng g−1	Induce aggressive behaviour	65
11	Mice	10 μg per kg per day for female BALB/c mice and 5 μg per kg per day for neonatal mice	Induce bronchial inflammation, allergic sensation and asthma	66
12	Rat	25 μg per kg per day and 300 μg per kg per day	Induce prostate gland impairment	67