Table7.

Treatments of cerebellar ataxia

Therapeutic Interventions for Cerebellar Ataxia
Targeted disease-modifying therapy for acquired disorders	Wernicke encephalopathy & chronic alcohol use Immune-mediated Paraneoplastic Gluten-associated ataxia	Thiamine, 1500 mg, IV daily × 2 d then 250 mg daily × 5 d Thiamine, 100 mg, PO daily Methylprednisolone, 1000 mg, IV × 3–5 d ± IVIG Methylprednisolone, 1000 mg, IV × 5 d + IVIG/plasmapheresis Gluten-free diet
Targeted disease-modifying therapy for inherited disorders	Niemann-Pick type C Abetalipoproteinemia GLUT-1 deficiency Cerebrotendinous xanthomatosis	Miglustat 200 mg TID Vitamin E, 150 mg/kg/d Ketogenic diet, avoid fasting Chenodeoxycholic acid, 250 mg, TID
Symptomatic therapy	Cerebellar ataxia SCA3 Episodic ataxia type 1 Episodic ataxia type 2	Riluzole, 50 mg, BID Varenicline, 1 mg, BID Carbamazepine Acetazolamide, 250–1000 mg/d, 4-aminopyridine, 15 mg/d

Abbreviations: BID, twice daily; d, day(s); GLUT, glucose transporter; IV, intravenous; IVIG, intravenous immunoglobulins; kg, kilograms; mg, milligrams; TID, three times per day.