Figure 2.

Body weights of treated MCK mice post-administration. The average life span of untreated MCK mice is 11 weeks.²⁴ As a measure of overall health, MCK mice were weighed at regular intervals after vector or PBS treatment until they became moribund (Supplementary Table S1). The mean weights (g) ± SEM are shown for time of assessment after vector administration, with males (squares) and females (triangles) separately. All mice were treated at 7 weeks of age ±1–2 days. Group 1 mice (1.8 × 10¹¹ gc/kg dose, blue symbols); Group 2 mice (5.7 × 10¹¹ gc/kg dose, green symbols); Group 3 mice (1.8 × 10¹² gc/kg, red symbols); Group 4 mice (PBS controls, gray symbols). (A) Males; (B) Females. MCK, muscle creatine kinase (mck)-Cre conditional knockout Fxn mouse model; PBS, phosphate-buffered saline.