Table 2.

Off-Target Analysis of Selected PAM Derivatives at 45 Other Receptors, Transporters, and Channels, As Determined in Radioligand Binding Assays by the PDSP^a

derivative	protein	Ki (μM)
14	5HT2B	1.36
	σ 1	1.48
	σ 2	1.36
18	σ 1	4.64
	σ 2	0.575
20	σ 1	5.15
	σ 2	0.907
21	σ 2	3.62
22	D3	5.28
23	D3	7.63
	σ 1	3.02
	σ 2	2.84
26	σ 1	2.34
	σ 2	1.34
27	MOR	7.22
	σ 1	2.42
	σ 2	3.43
	KOR	5.50
	DAT	0.467
	5HT2B	3.25
35	D3	0.846
	TSPO	0.427
	σ 2	3.01
39	5HT2B	2.60
	TSPO	0.123
	σ 2	0.891

^aThese are the only hits with >50% inhibition in the primary screen at 10 μM.