Table 1:
Baboons and Pigs studied.
| Animal (Sex) | Age (Mo) | Timing Date | Weight (kg) | Inulin | Cr CL/ GFR (ml/min) | Cefoxitin | ||
|---|---|---|---|---|---|---|---|---|
| Bolus (mg) | Infusion (mg/kg/hr) | Bolus (mg) | Clearance (ml/min) | |||||
| Baboons | ||||||||
| B1717 (M) | 44 | Naïve 121720 |
10.5 | 410 | 158 | 135 | N/A | N/A |
| Naïve 011221 |
10.5 | 410 | 158 | 102 | N/A | N/A | ||
| B4017 (M) | 41 | Naïve 021821 |
11.75 | 468 | 176 | 15 | N/A | N/A |
| B4218 (M) | 32 | Naïve 040621 |
9.5 | 371 | 143 | 58 | 48 | 86.4 |
| B5618 (F) | 29 | POD10 031821 |
7.5 | 293 | 113 | 34 | 38 | 23.6 |
| B14016 (F) | 52 | POD21 032921 |
13.5 | 526 | 203 | 11 | 68 | 67.4 |
| B1318 (M) | 34 | POD188 011121 |
6.8 | 265 | 102 | 1.5 | N/A | N/A |
| B7018 (M) | 30 | Naïve 041321 |
10.1 | 394 | 151 | 57 | 50 | 3.6 |
| POD7 051021 |
9.4 | 366 | 141 | 14 | 45 | 54.4 | ||
| POD31 060321 |
9.4 | 366 | 141 | 12 | 45 | 66.3 | ||
| POD38 061021 |
9.4 | 366 | 141 | 31 | 45 | 34.1 | ||
| B4918 (M) | 30 | Naïve 042221 |
9.1 | 65 | 45 | 84.1 | ||
| POD9 051221 |
9.1 | 354.9 | 137 | 30 | 45 | 77.3 | ||
| POD37 060921 |
9.1 | 354.9 | 137 | 67 | 45 | -3.6 | ||
| POD44 061621 |
9.1 | 354.9 | 137 | 52 | 45 | 127.6 | ||
| Pigs | ||||||||
| 355399 | 1.5 | Naïve 042021 |
41.0 | 1599 | 615 | 127 | 200 | 453.5 |
| 355400 | 2 | Naïve 042621 |
41.0 | 1599 | 615 | 99 | 200 | 160.0 |
| A340-5 | 5 | GE 052621 |
73.9 | 2882 | 1109 | 178 | 370 | 269.4 |
Notes: Control animals (healthy baboons and healthy pigs) are indicated as naïve. M indicates male sex; F indicates female sex. Age is listed at the time of the first study. Bilaterally nephrectomized baboons with a life-supporting pig kidney graft are indicated as naïve pre-transplant and by post-operative day (POD) following transplantation. Weight refers to the weight (in kg) of the animal at the time of the study. Secretory clearance was determined as renal clearance of cefoxitin minus creatinine clearance and is reported as milliliter perminute. N/Ameans the experimentwas not performed (mainly due to lack of availability of cefoxitin for research purposes during the initial COVID-19 pandemic). Genotype of source pig for renal xenotransplant to B7018 and B4918 was GTKO.CD46.TBM. For B5618 and B14016 it was GTKO.CD46.DAF.TBM.EPCR. For B1318 it was GTKO.β4GalNT2KO.CD46.TBM.EPCR.CD47.GHRKO. The genotype of A340-5was 9-gene GTKO.CMAHKO.B4KO.CD46.DAF.TBM.EPCR.CD47.HO1.
Abbreviations: GE, refers to genetically engineered pig; GFR, glomerular filtration rate.