Table 6.

ROC curve analysis and cut-off values of bipolar disorder in different states.

Variables	Area	p-value	95%CI		Cut-off value
			Lower limit	Upper limit
HG vs BD
MON	0.704	<0.0001	0.653	0.754	0.405
hs-CRP	0.582	0.010	0.533	0.631	2.600
NLR	0.622	<0.0001	0.571	0.673	2.321
MON+ hs-CRP	0.727	<0.0001	0.680	0.774	NA
MON+NLR	0.732	<0.0001	0.684	0.779	NA
hs-CRP + NLR	0.667	<0.0001	0.620	0.713	NA
MON+ hs-CRP + NLR	0.746	<0.0001	0.701	0.790	NA
HG vs BD-M
MON	0.726	<0.0001	0.675	0.777	0.505
hs-CRP	0.628	<0.0001	0.575	0.681	2.600
NLR	0.639	<0.0001	0.585	0.693	2.620
MON+ hs-CRP	0.757	<0.0001	0.710	0.805	NA
MON+ NLR	0.756	<0.0001	0.708	0.803	NA
hs-CRP+ NLR	0.697	<0.0001	0.648	0.747	NA
MON+ hs-CRP+ NLR	0.775	<0.0001	0.729	0.820	NA
HG vs BD-D
NLR	0.587	0.030	0.509	0.665	1.735
MHR	0.626	0.002	0.551	0.702	0.487
NLR+ MHR	0.652	<0.0001	0.578	0.726	NA
HG vs BD with mixed features
MON	0.740	<0.0001	0.655	0.826	0.340

HG, Healthy group; BD, bipolar disorder; BD-M, bipolar disorder manic episodes; BD-D, bipolar disorder depressive episodes; BD with mixed features, bipolar disorder with mixed features; MON, monocyte; hs-CRP, hypersensitive C-reactive protein; NLR, Neutrophil-to-lymphocyte ratio; MHR, Monocyte-to-HDL ratio.