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. 2023 Jul 18;23:514. doi: 10.1186/s12888-023-05014-1

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — Effects of minocycline and antipsychotics on MAPKs inflammatory signaling pathway in BV-2 microglial cells. The cells were randomly divided into 5 groups. The blank control group was treated with nothing, the LPS group was treated with 1.0 ug/ml LPS for 24 h. The three drug groups were pretreated with 10 μmol/L minocycline, 10 μmol/L risperidone and 50 μmol/L haloperidol respectively for 24 h, and then 1.0 ug/ml LPS was added for 24 h. The band density was used to quantify the expression levels of JNK, ERK, and pho-p38/ p38 normalized with a band density of α-Tubulin (A). The expression of the proteins was determined by western blot analysis (B). ^##p < 0.01 and ^###p < 0.001 were compared with the blank control group; *p < 0.05, **p < 0.01 and ***p < 0.001 were compared with the LPS group. The original image of the full gels/blots was included in the Supplementary Fig. S2, Fig.S3, Fig.S4, and Fig.S5.