Table 2.

The PANSS total score change from baseline and reduction rate of PANSS total score after 8-week treatment, stratified by baseline illness severity

	Olanzapine group	Risperidone group	Amisulpride group	Aripiprazole group	Post-hoc Analysis
					Olanzapine vs risperidone	Olanzapine vs amisulpride	Olanzapine vs aripiprazole	Risperidone vs amisulpride	Risperidone vs aripiprazole	Amisulpride vs aripiprazole
All patients
PANSS total score change from baseline	16.24 ± 11.24	15.70 ± 10.58	16.09 ± 10.42	12.22 ± 9.40	0.588	0.882	< 0.001	0.694	0.001	< 0.001
Reduction rate of PANSS total score (%)	29.0 ± 16.9	29.0 ± 17.2	29.2 ± 17.0	23.7 ± 16.4	0.983	0.877	0.002	0.892	0.002	0.001
Severe schizophrenia (PANSS total score > 95)
PANSS total score change from baseline	22.64 ± 16.49	25.05 ± 14.32	22.69 ± 12.58	15.69 ± 12.77	0.432	0.987	0.021	0.435	0.003	0.018
Reduction rate of PANSS total score (%)	29.6 ± 19.6	33.3 ± 18.6	30.9 ± 17.5	19.3 ± 14.9	0.339	0.716	0.006	0.535	< 0.001	0.002
Moderate schizophrenia (95 ≥ PANSS total score > 75)
PANSS total score change from baseline	16.48 ± 9.39	14.87 ± 8.84	15.89 ± 9.69	11.84 ± 9.10	0.173	0.618	0.001	0.388	0.030	0.004
Reduction rate of PANSS total score (%)	30.0 ± 17.2	28.0 ± 17.2	29.6 ± 18.3	23.3 ± 18.4	0.375	0.874	0.013	0.466	0.078	0.018
Mild schizophrenia (75 ≥ PANSS total score > 58)
PANSS total score change from baseline	10.45 ± 5.39	11.28 ± 6.75	10.43 ± 6.25	10.43 ± 6.25	0.459	0.931	0.986	0.415	0.418	0.940
Reduction rate of PANSS total score (%)	26.2 ± 13.2	28.2 ± 16.1	26.6 ± 12.8	27.0 ± 14.3	0.437	0.885	0.793	0.539	0.574	0.918

Data are presented as means ± standard deviations

PANSS Positive and Negative Syndrome Scale