Table 1.
Pleiotropy and heterogeneity tests for the causal link between serum urate levels and the risk of venous thromboembolism
| Pleiotropy | Heterogeneity | |||
|---|---|---|---|---|
| MR-Egger intercept test | MR-PRESSO global test | Cochran’s Q test | ||
| IVW | ||||
| Intercept | Pval | Pval | Pval | |
| Urate (CKDGen) vs. VTE | 0.009 | 9.88E−04 | < 5e−04 | 1.44E−06 |
| Urate (CKDGen) vs. DVT | 0.008 | 0.017 | 0.0175 | 0.013 |
| Urate (CKDGen) vs. PE | 0.012 | 6.55E−04 | 0.014 | 0.013 |
| Urate (UKB) vs. VTE | 0.002 | 0.418 | < 5e−04 | 4.28E−14 |
| Urate (UKB) vs. DVT | 0.006 | 0.038 | < 5e−04 | 1.18E−05 |
| Urate (UKB) vs. PE | 4.46E−04 | 0.866 | < 5e−04 | 6.20E−06 |
CKDGen The Chronic Kidney Disease Genetics consortium, UKB UK biobank, IVW Inverse variance weighted analysis, VTE venous thromboembolism, DVT Deep vein thrombosis of the lower extremities, PE Pulmonary embolism