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. 2023 Jul 18;15:53. doi: 10.1186/s13073-023-01205-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — CX3CR1 expression is reduced in peripheral myeloid and lymphoid cells in familial tauopathy. A CX3CR1 is robustly expressed in both NC monocytes (cluster 11) and NK cells (cluster 3). NC monocytes (B; p_FDR = 5.6 × 10⁻⁴⁶) and NK cells (C; p_FDR = 2.6 × 10⁻¹²⁰) both show significantly reduced expression of CX3CR1 in MAPT pathogenic variant carriers. D Reanalysis of publicly available bulk RNA-seq data from mouse hippocampal CD11b⁺ microglia demonstrated a significant reduction (p_FDR = 2.5 × 10⁻⁷) of Cx3cr1 in the MAPT P301S model