Fig. 5.

Validation of shared and divergent CSF protein levels across AD and race. A Schematic of experimental workflow for SRM analysis of cerebrospinal fluid proteome B Heatmap of peptides that were significantly differentially expressed between control and AD Caucasians or African Americans. Stars are indicative of the level of significant difference (*p ≤ 0.05; **p ≤ 0.01; ***p ≤ 0.001) seen for each peptide between AD and control within each race. Meanwhile the colors are indicative of the log₂ fold change (FC) of each peptide from control and AD for each race where blue is indicative of the degree of decrease and shade of red is indicative of the degree of increase. C Log₂ abundance of peptides that mapped to modules of interest distributed by race and diagnosis. Pairwise significance was calculated using one-way ANOVA with Tukey adjustment