Table 3.
Mechanically ventilated validation cohort
| Characteristics | Healthy (n = 50) | MV patients (n = 193, kg/m2) | P-value | ||
|---|---|---|---|---|---|
| 18.5–24 (n = 90) | ≥ 24 (n = 48) | < 18.5 (n = 55) | |||
| MMP-8, ng/ml | 2.702 (2.305–3.313) | 2.961 (2.447–3.611) | 2.763 (1.923–3.753) | 3.717 (2.628–4.191) | 0.030*, 0.002+ |
| Sex, female (n%) | 30 (12.3%) | 39 (16%) | 17 (7%) | 24 (9.9%) | 0.019*, 0.619+ |
| Age < 60, years (n%) | 40 (16.5%) | 61 (25.1%) | 29 (11.9%) | 34 (14%) | 0.034*, 0.626+ |
| BMI, kg/m2 | 21.95 (19.8–22.5) | 22.95 (21.5–23.7) | 24.8 (24.1–26.05) | 17.9 (17.0–18.0) | 0.193*, < 0.001+ |
| aCCI | 0 (0–2) | 2 (1–3) | 2 (1–4) | 2 (1–4) | < 0.001*, 0.998+ |
| SOFA | 4 (3–5) | 9 (8–11) | 10 (8–11.5) | 10 (8–12) | < 0.001*, 0.406+ |
| MAP, mmHg | 56 (51–83) | 75 (60–98) | 74 (64.5–90.5) | 73 (61–82) | 0.003*, 0.689+ |
| FIO2 | 21 (21–21) | 45 (37–54) | 47 (40–50.5) | 50 (41–60) | < 0.001*, 0.057+ |
| PCO2, mmHg | 42 (35–43) | 37 (31–42) | 37 (34–40.5) | 39 (31–44) | 0.007*, 0.448+ |
| PaO2, mmHg | 94 (89–98) | 101.5 (78–116) | 92 (77–119.5) | 105 (88–131) | 0.101*, 0.234+ |
| WBC, 1012/L | 8.88 (7.2–10.62) | 15.865 (11.93–19.4) | 14.88 (10.31–16.76) | 15.1 (9.72–18.24) | < 0.001*, 0.259+ |
| PLT, 109/L | 133.5 (123–144) | 127 (83–164) | 136 (66.5–159.1) | 124.5 (63–169) | 0.084*, 0.994+ |
| Lac, mmol/L | 0.73 (0.41–0.77) | 5 (2.98–7.93) | 4.925 (3.245–7.05) | 4.22 (2.64–7.67) | < 0.001*, 0.593+ |
| APTT, S | 32.7 (31.5–37.8) | 50.9 (41.2–60.6) | 51.3 (42.85–64.2) | 52.2 (41.9–64.2) | < 0.001*, 0.544+ |
| Urine, mL | 1303 (1203–1550) | 1525 (1000–2150) | 1660 (1187–2065) | 1646.3 (945–2000) | 0.090*, 0.548+ |
| ALT, U/L | 17.5 (12–41) | 35 (14–84) | 21.5 (14.5–46.5) | 36 (14–159) | 0.011*, 0.269+ |
| AST, U/L | 21 (16–29) | 47 (23–111) | 45 (23.5–76.5) | 60 (25–261) | < 0.001*, 0.460+ |
| BUN, mmol/L | 4.39 (3.2–5.43) | 10.55 (6.55–18) | 11.25 (7.175–16) | 9.15 (6.41–19.6) | < 0.001*, 0.890+ |
| Cr, µmol/L | 55.125 (48–73) | 144 (67–271) | 141 (84.5–272) | 115 (75–237) | < 0.001*, 0.564+ |
| Co-morbidities | – | ||||
| CHF | – | 22 (11.40%) | 7 (3.63%) | 13 (6.74%) | 0.378 |
| Renal failure | – | 37 (19.17%) | 20 (10.36%) | 20 (10.36%) | 0.817 |
| Hepatic failure | – | 46 (23.83%) | 22 (11.40%) | 31 (16.06%) | 0.566 |
| Sepsis | 77 (39.90%) | 42 (21.76%) | 43 (22.28%) | 0.372 | |
| ARDS | – | 68 (35.23%) | 37 (19.17%) | 44 (22.80%) | 0.825 |
*: Comparisons between healthy and mechanically ventilated groups. + : Within MV subgroup comparisons. IHM, In-hospital mortality; CHF, Congestive Heart Failure; MV, Mechanical Ventilation