Table 3.
Correlation of miR-483-5p levels with clinical information of ACS patients
| Parameters | low miR-483-5p group (n = 56) |
high miR-483-5p group (n = 62) |
P values |
|---|---|---|---|
| Age, years | 59.68 ± 8.24 | 58.02 ± 7.64 | 0.259 |
| BMI, kg/m2 | 26.25 ± 4.09 | 27.225 ± 3.95 | 0.191 |
| Gender, male, n (%) | 30 (53.57) | 38 (61.29) | 0.489 |
| Smoking, n (%) | 33 (58.93) | 31 (50.00) | 0.318 |
| SBP, mmHg | 130.68 (123.75, 135.63) | 128.70 (123.50, 136.62) | 0.612 |
| DBP, mmHg | 82.20 (77.45, 87.10) | 82.20 (74.98, 88.10) | 0.983 |
| LDL-C, mmol/L | 2.70 (2.00, 3.05) | 2.95 (2.38, 3.53) | 0.025 |
| HDL-C, mmol/L | 1.38 (1.02, 1.68) | 1.24 (0.83, 1.57) | 0.019 |
| TC, mmol/L | 4.14 ± 0.49 | 4.08 ± 0.40 | 0.429 |
| TG, mmol/L | 1.23 ± 0.56 | 1.50 ± 0.57 | 0.437 |
| Creatine, µmol/L | 74.39 (68.62, 78.50) | 73.25 (69.08, 78.21) | 0.602 |
| WBC, ×109/L | 7.42 ± 0.67 | 7.40 ± 0.75 | 0.859 |
| UREA, mmol/L | 4.92 ± 0.52 | 4.85 ± 0.49 | 0.479 |
| NT-proBNP, pg/mL | 102.74 ± 36.64 | 118.36 ± 34.63 | 0.019 |
| hs-CRP, mg/L | 5.82 ± 1.52 | 6.11 ± 1.26 | 0.255 |
| cTnI, ng/mL | 0.55 (0.28, 1.63) | 0.71 (1.00, 2.38) | 0.000 |
| SYNTAX score | 26.03 ± 10.60 | 30.83 ± 10.65 | 0.016 |
| Gensini score | 40.80 ± 22.13 | 55.96 ± 28.53 | 0.002 |
| Culprit lesion, n (%) | |||
| Left main | 0 (0.00) | 1 (1.61) | 0.340 |
| Left anterior descending | 17 (30.36) | 25 (40.32) | 0.259 |
| Left circumflex | 10 (17.86) | 19 (30.65) | 0.107 |
| Right | 28 (50.00) | 18 (29.03) | 0.412 |
| Baseline stenosis (%) | 92.09 ± 3.70 | 95.81 ± 3.11 | 0.000 |
| MVD, n (%) | 34 (60.72) | 39 (62.90) | 0.807 |
| Stent diameter (mm) | 2.90 ± 0.48 | 3.21 ± 0.44 | 0.003 |
| Stent length (mm) | 25.86 ± 4.54 | 27.08 ± 4.36 | 0.139 |
| Aspirin/clopidogrel, n (%) | 7 (12.50) | 11 (26.81) | 0.429 |
| ACE inhibitor/ARB, n (%) | 15 (26.79) | 16 (25.81) | 0.904 |
| β-blocker, n (%) | 11 (19.64) | 14 (22.58) | 0.679 |
| Calcium Channel blocker, n (%) | 5 (8.93) | 7 (11.29) | 0.672 |
| Stain, n (%) | 5 (8.93) | 13 (20.97) | 0.069 |
| Subgroups of ACS patients | |||
| UAP/AMI | 35/21 | 5/57 | 0.000 |
Note: ACE, angiotensin converting enzyme; ARB, angiotensin receptor blocker; BMI, body mass index; SBP, systolic blood pressure; DBP, diastolic blood pressure; HDL-C, high-density lipoprotein cholesterol; LDL, low-density lipoprotein cholesterol; MVD, multivessel disease; TC, total cholesterol; TG, triglyceride; WBC, white blood cells; hs-CRP, high-sensitivity C-reactive protein; cTnI, cardiac troponin I; Date was presented as mean ± SD, or median (first quartile, third quartile), or N (%)