Optimization of reaction conditions^a.

Entrya	Variation from standard conditions	Yieldb
1	None	99%c (97%)
2	Mn instead of Zn	n.o.
3	Fe instead of Zn	n.o.
4	Toluene instead of MeCN	<5%
5	No catalyst	n.o.
6	No ligand	Trace
7	Pd(TFA)2 instead of Pd(OAc)2	94%
8	Xantphos instead of DPPP	31%
9	Ni(acac)2 + L1 as catalyst	n.o.
10	CuI + L1 as catalyst	n.o.
11	1 bar CO	91%

^aReaction conditions: 1a (0.2 mmol), 2a (0.3 mmol), CO (10 bar), Pd(OAc)₂ (1 mol%), DPPP (1 mol%), Zn (0.3 mmol) in MeCN (2 mL) at 80 °C for 20 h.

^bYields were determined by GC-FID analysis using n-dodecane as the internal standard.

^cYield of the isolated product. n.o. = not observed.