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. 2023 Jun 22;14(28):7709–7715. doi: 10.1039/d3sc01849k

The scope studiesa.

graphic file with name d3sc01849k-u3.jpg
a

Unless otherwise indicated, the reaction was performed with 1 mmol of 1, 1.0 equiv. of 2, 1.5 equiv. of 3, 6 or 8, 2.5 mol% of [Pd(allyl)Cl]2, 12 mol% of SPhos, and 2.0 equiv. of K2CO3 in DCE (0.1 M) at 50 °C for 24 h. Yields of isolated products are given.

b

5 mol% of [Pd(allyl)Cl]2 and 24 mol% of SPhos were used. The reaction was run for 48 h.

c

3.5 mol% of [Pd(allyl)Cl]2 and 15 mol% of SPhos were used. The reaction was run for 36 h.

d

3.5 mol% of [Pd(allyl)Cl]2, 15 mol% of SPhos, and 2.0 equiv. of 3a were used. The reaction was run for 36 h.

e

The reaction was run for 36 h.

f

3.5 mol% of [Pd(allyl)Cl]2 and 15 mol% of SPhos were used. The reaction was run for 48 h.

g

2.0 equiv. of Cs2CO3 were used instead of K2CO3. The reaction was run for 48 h.

h

The reaction was performed with 1 mmol of 1, 1.0 equiv. of 2a, 2 equiv. of 3, 3.5 mol% of [Pd(allyl)Cl]2, 15 mol% of SPhos, and 2.0 equiv. of Cs2CO3 in DCE (0.1 M) at 50 °C for 48 h.