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. 2023 Jul 5;14:1190844. doi: 10.3389/fimmu.2023.1190844

Figure 4.

Figure 4

Identification and characteristic analysis of COVID-19-associated T cell receptor (TCR) β clones. (A) Differences in the detected clones between the COVID-19 and healthy control (HC) groups (Fisher’s exact test). The horizontal axis is the clone’s relative risk (RR) index and the vertical axis is the FDR value after correction using Fisher’s exact test. (B) Distribution of the clone detection sample numbers between the COVID-19 and HC groups. (C) Comparison of COVID-19-specific, protective, and random clones in terms of CDR3 length, CDR3 sequence similarity, and clone abundance. (D) Similarity network of the CDR3 sequences of the clones with a difference in FDR values of < 0.001 between the COVID-19 and HC groups. Clones identified as dark red dots are COVID-19-specific clones, whereas those identified as light green dots are protective clones. The size of the dot represents the clone’s cumulative frequency in all samples. (E) Similarity network of CDR3 sequences in the 1000 clones (dominant clones) with the highest frequency in the COVID-19 and HC groups. The node degree of the cluster graph in (D, E) is > 2.