Table 1.
The relationship between cytoplasmic S100A2 status and clinical characteristic in CRC patients
| Low expression of S100A2 N=177 (%) | High expression of S100A2 N=442 (%) | P value | |
|---|---|---|---|
| Host characteristics | |||
| Sex | 0.197 | ||
| Female | 72 (41) | 205 (47) | |
| Male | 105 (59) | 237 (53) | |
| Age | 0.557 | ||
| <65 | 50 (28) | 144 (33) | |
| 65-74 | 61 (35) | 139 (31) | |
| >75 | 66 (37) | 159 (36) | |
| Tumour characteristic | |||
| MMR status | 0.063 | ||
| dMMR | 40 (23) | 67 (15) | |
| pMMR | 105 (60) | 300 (69) | |
| Tumour site | 0.709 | ||
| Right | 70 (40) | 182 (41) | |
| Left | 107 (60) | 260 (59) | |
| Local recurrence* | 0.027 | ||
| No | 140 (86) | 387 (92) | |
| Yes | 22 (14) | 32 (8) | |
| Distant recurrence* | 0.034 | ||
| No | 119 (74) | 342 (81) | |
| Yes | 43 (43) | 78 (19) | |
| TNM stage | <0.001 | ||
| I | 11 (7) | 72 (16) | |
| II | 79 (45) | 217 (49) | |
| III | 87 (49) | 153 (35) | |
| T stage | 0.009 | ||
| 1 | 5 (3) | 22 (5) | |
| 2 | 12 (7) | 59 (13) | |
| 3 | 101 (57) | 260 (59) | |
| 4 | 59 (33) | 101 (23) | |
| N stage | 0.003 | ||
| 0 | 90 (51) | 289 (65) | |
| 1 | 62 (35) | 112 (25) | |
| 2 | 25 (14) | 41 (9) | |
| Margin involvement | 0.159 | ||
| No | 163 (92) | 420 (95) | |
| Yes | 14 (8) | 22 (5) | |
| Peritoneal involvement | 0.013 | ||
| No | 125 (71) | 353 (80) | |
| Yes | 52 (29) | 89 (20) | |
| Perineural invasion* | <0.001 | ||
| No | 44 (61) | 193 (85) | |
| Yes | 28 (39) | 35 (15) | |
| Tumour perforation | 0.718 | ||
| No | 173 (98) | 434 (98) | |
| Yes | 4 (2) | 8 (2) | |
| Venous invasion | 0.394 | ||
| No | 92 (52) | 213 (48) | |
| Yes | 85 (48) | 229 (52) | |
| TBa | 0.619 | ||
| Low | 125 (72) | 297 (70) | |
| High | 48 (28) | 126 (30) | |
| KI67a | <0.001 | ||
| Low | 71 (51) | 104 (27) | |
| High | 69 (49) | 285 (73) | |
| Tumour microenvironment | |||
| TSP* | 0.080 | ||
| Low | 129 (74) | 340 (80) | |
| High | 46 (26) | 84 (20) | |
| KM* | 0.357 | ||
| Low | 149 (86) | 350 (83) | |
| High | 25 (14) | 74 (17) | |
| GMS* | 0.129 | ||
| 0 | 25 (14) | 74 (17) | |
| 1 | 106 (61) | 275 (65) | |
| 2 | 43 (25) | 75 (18) | |
| mGPS | 0.002 | ||
| 0 | 101 (57) | 292 (66) | |
| 1 | 54 (31) | 79 (18) | |
| 2 | 22 (12) | 71 (16) |
dMMR = deficient mismatch repair, pMMR = proficient mismatch repair, TB =Tumour budding, TSP = Tumour stroma percentage, KM = Klintrup-Mäkinen, GMS = Glasgow Microenvironment Score, mGPS = modified Glasgow prognostic score
* some data missing from clinical record
a some data not available